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CS-W001157 4
Total: USD 88.00

(S)-4-Ethyl-4-hydroxy-11-methyl-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

  • CAS No. 78287-26-0

  • Cat. No. CS-0044427
  • Purity≥95%
  • MDL No.MFCD09833230

*For research and further manufacturing use only, not for direct human use.

(S)-4-Ethyl-4-hydroxy-11-methyl-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione|CS-0044427

Structure of 78287-26-0

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General Information

  • CAS No. 78287-26-0
  • Cat. No. CS-0044427
  • Purity ≥95%
  • MDL No. MFCD09833230
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₁₈N₂O₄
  • Molecular Weight 362.38
  • Synonym(s) 7-Methylcamptothecin
  • SMILES O=C1N(CC2=C3C)C(C2=NC4=CC=CC=C34)=CC([C@](O)5CC)=C1COC5=O

Synthesis

  • Route1
    • null|null
      75-91-2
    • (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Irinotecan Impurity|CS-0167146
      7689-03-4
    • ~99%
    • In-stock
      (S)-4-Ethyl-4-hydroxy-11-methyl-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione|CS-0044427
      78287-26-0

    References

    • Wang, Xin; Wen, Jiwu; Li, Gang; You, Tianpa Synthetic Communications, 2005 , vol. 35, # 24 p. 3163 - 3166
  • Route2
    • null|null
      64-19-7
    • (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Irinotecan Impurity|CS-0167146
      7689-03-4
    • ~83%
    • In-stock
      (S)-4-Ethyl-4-hydroxy-11-methyl-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione|CS-0044427
      78287-26-0

    References

    • Ahn, Soon Kil; Choi, Nam Song; Jeong, Byeong Seon; Kim, Kye Kwang; Journ, Duck Jin; Kim, Joon Kyum; Lee, Sang Joon; Kim, Jung Woo; Hong, Chung Il; Jew, Sang-sup Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 5 p. 1141 - 1144
  • Route3
    • null|null
      64-17-5
    • (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Irinotecan Impurity|CS-0167146
      7689-03-4
    • ~39%
    • In-stock
      (S)-4-Ethyl-4-hydroxy-11-methyl-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione|CS-0044427
      78287-26-0
    • null|null
      96962-25-3

    References

    • Sawada; Nokata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2574 - 2580

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   81.42
  • LogP   2.38802
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   1

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