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CS-W001157 4
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tert-Butyl4-(pyrimidin-2-yl)piperazine-1-carboxylate

  • CAS No. 780705-64-8

  • Cat. No. CS-0171800
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl4-(pyrimidin-2-yl)piperazine-1-carboxylate|CS-0171800

Structure of 780705-64-8

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General Information

  • CAS No. 780705-64-8
  • Cat. No. CS-0171800
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₀N₄O₂
  • Molecular Weight 264.32
  • Synonym(s) 1-N-Boc-4-Pyrimidin-2-yl-piperazine
  • SMILES CC(C)(C)OC(=O)N1CCN(CC1)C2=NC=CC=N2

Synthesis

  • Route1
    • In-stock
      2-Chloropyrimidine|CS-W008600
      1722-12-9
    • N-Boc-piperazine Olaparib Impurity|CS-0214004
      57260-71-6
    • ~81%
    • In-stock
      tert-Butyl4-(pyrimidin-2-yl)piperazine-1-carboxylate|CS-0171800
      780705-64-8

    References

    • Larsen, Matthew A.; Hartwig, John F. Journal of the American Chemical Society, 2014 , vol. 136, # 11 p. 4287 - 4299
  • Route2
    • In-stock
      2-Bromopyrimidine|CS-W009110
      4595-60-2
    • N-Boc-piperazine Olaparib Impurity|CS-0214004
      57260-71-6
    • ~47%
    • In-stock
      tert-Butyl4-(pyrimidin-2-yl)piperazine-1-carboxylate|CS-0171800
      780705-64-8

    References

    • Salituro, Francesco G.; Saunders, Jeffrey O.; Yan, Shunqi Patent: US2010/331307 A1, 2010 ; Location in patent: Page/Page column 27 ; US 20100331307 A1
  • Route3
    • 2-(1-Piperazinyl)pyrimidine Buspirone Impurity|CS-0229565
      20980-22-7
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • ~99%
    • In-stock
      tert-Butyl4-(pyrimidin-2-yl)piperazine-1-carboxylate|CS-0171800
      780705-64-8

    References

    • Varala, Ravi; Nuvula, Sreelatha; Adapa, Srinivas R. Journal of Organic Chemistry, 2006 , vol. 71, # 21 p. 8283 - 8286

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   58.56
  • LogP   1.5337
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   1

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