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CS-W001157 4
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(5-Bromo-2-chlorophenyl)boronic acid

  • CAS No. 774608-50-3

  • Cat. No. CS-0175198
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(5-Bromo-2-chlorophenyl)boronic acid|CS-0175198

Structure of 774608-50-3

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General Information

  • CAS No. 774608-50-3
  • Cat. No. CS-0175198
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BBrClO₂
  • Molecular Weight 235.27
  • Synonym(s) 5-Bromo-2-chlorophenylboronic acid
  • SMILES BrC1=CC(B(O)O)=C(Cl)C=C1

Description

This boronic acid features a bromo-chloro-substituted phenyl core, enabling efficient coupling in palladium-catalyzed reactions. The electron-deficient aromatic ring enhances reactivity while maintaining bench stability under standard conditions. Designed for streamlined integration into complex molecular architectures.

Application

(5-Bromo-2-chlorophenyl)boronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under standard Suzuki-Miyaura conditions. Its compatibility with diverse reaction partners and stability under ambient storage make it ideal for constructing complex aryl scaffolds in medicinal chemistry and materials synthesis.

Synthesis

  • Route1
    • In-stock
      4-Bromo-1-chloro-2-iodobenzene|CS-0042267
      774608-49-0
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      121-43-7
    • ~%
    • In-stock
      (5-Bromo-2-chlorophenyl)boronic acid|CS-0175198
      774608-50-3

    References

    • SYNGENTA LIMITED Patent: WO2008/145336 A1, 2008 ; Location in patent: Page/Page column 65-66 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P280-P304+P340-P405

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.7823
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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