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CS-W001157 4
Total: USD 88.00

(3-Bromo-2-chlorophenyl)boronic acid

  • CAS No. 352535-98-9

  • Cat. No. CS-0107814
  • Purity≥97%
  • MDL No.MFCD13184263

*For research and further manufacturing use only, not for direct human use.

(3-Bromo-2-chlorophenyl)boronic acid|CS-0107814

Structure of 352535-98-9

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General Information

  • CAS No. 352535-98-9
  • Cat. No. CS-0107814
  • Purity ≥97%
  • MDL No. MFCD13184263
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BBrClO₂
  • Molecular Weight 235.27
  • Synonym(s) 3-BROMO-2-CHLOROPHENYLBORONIC ACID
  • SMILES ClC1=C(Br)C=CC=C1B(O)O

Description

(3-Bromo-2-chlorophenyl)boronic acid features a sterically accessible boronate moiety flanked by bromo and chloro substituents, enabling efficient cross-coupling in palladium-catalyzed transformations. This bench-stable reagent integrates seamlessly into synthetic workflows requiring halogen-directed functionalization, delivering high chemoselectivity under standard conditions.

Application

(3-Bromo-2-chlorophenyl)boronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation with aryl halides and triflates. The molecule exhibits excellent bench stability, tolerates diverse functional groups, and facilitates straightforward purification via crystallization or standard chromatography. Its dual halogenation pattern supports sequential functionalization strategies in the synthesis of complex biaryl architectures and heterocyclic scaffolds relevant to medicinal chemistry and materials science.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.7823
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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