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CS-W001157 4
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tert-Butyl (2R,4S)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

  • CAS No. 77450-03-4

  • Cat. No. CS-0060904
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (2R,4S)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate|CS-0060904

Structure of 77450-03-4

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General Information

  • CAS No. 77450-03-4
  • Cat. No. CS-0060904
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉NO₄
  • Molecular Weight 217.26
  • Synonym(s) (2R,4S)-tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate
  • SMILES CC(C)(C)OC(=O)N1C[C@H](C[C@@H]1CO)O

Synthesis

  • Route1

    References

    • Jing, Qing; Li, Huiying; Roman, Linda J.; Martasek, Pavel; Poulos, Thomas L.; Silverman, Richard B. ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 1 p. 56 - 60
  • Route2
    • (2R,4R)-1-tert-Butyl 2-ethyl 4-hydroxypyrrolidine-1,2-dicarboxylate|CS-0434697
      77450-00-1
    • ~80%
    • In-stock
      tert-Butyl (2R,4S)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate|CS-0060904
      77450-03-4

    References

    • Watanabe, Akiko; Kiyota, Naotoshi; Yamasaki, Tetsuo; Tanda, Kazuhiro; Miyagoe, Tatsunori; Sakamoto, Masanori; Otsuka, Masami Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 5 p. 1132 - 1139
  • Route3
    • null|null
      135042-16-9
    • ~99%
    • In-stock
      tert-Butyl (2R,4S)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate|CS-0060904
      77450-03-4

    References

    • Peterson, Mark L.; Vince, Robert Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2787 - 2797

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   70
  • LogP   0.349
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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