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CS-W001157 4
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(S)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)acetic acid

  • CAS No. 204688-61-9

  • Cat. No. CS-B0997
  • Purity≥97%
  • MDL No.MFCD05861546

*For research and further manufacturing use only, not for direct human use.

(S)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)acetic acid|CS-B0997

Structure of 204688-61-9

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General Information

  • CAS No. 204688-61-9
  • Cat. No. CS-B0997
  • Purity ≥97%
  • MDL No. MFCD05861546
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉NO₄
  • Molecular Weight 229.27
  • Synonym(s) [(3S)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]acetic acid
  • SMILES O=C(O)C[C@H]1CN(C(OC(C)(C)C)=O)CC1

Description

This chiral building block features a protected pyrrolidine ring fused to an acetic acid side chain, enabling direct incorporation into peptidomimetics and bioactive scaffolds. The tert-butoxycarbonyl group provides stability during synthesis, while the (S)-configuration ensures stereochemical fidelity in downstream applications.

Application

(S)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)acetic acid serves as a versatile chiral building block for the synthesis of pyrrolidine-containing pharmaceuticals and natural products. The protected pyrrolidine moiety enables efficient incorporation into complex scaffolds, while the pendant carboxylic acid facilitates coupling reactions. This compound exhibits excellent bench stability and is compatible with standard peptide coupling and reductive amination protocols, making it ideal for medicinal chemistry applications requiring stereocontrolled construction of nitrogen heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.7181
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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