Lot numbers can be found on the outside label of a product:
5-Bromo-7-methylindoline-2,3-dione
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CAS No. 77395-10-9
- Cat. No. CS-0139772
- Purity≥96%
- MDL No.MFCD00463080
*For research and further manufacturing use only, not for direct human use.
Structure of 77395-10-9
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General Information
- CAS No. 77395-10-9
- Cat. No. CS-0139772
- Purity ≥96%
- MDL No. MFCD00463080
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₆BrNO₂
- Molecular Weight 240.05
- Synonym(s) Isatin,5-bromo-7-methyl- (2CI)
- SMILES O=C1NC2=C(C=C(Br)C=C2C)C1=O
Description
5-Bromo-7-methylindoline-2,3-dione features a brominated indoline core with a methyl substituent at the 7-position, delivering enhanced electron-withdrawing character and improved solubility in polar organic solvents. This scaffold integrates readily into synthetic intermediates for pharmaceuticals and agrochemicals, offering high stability under standard handling conditions and compatibility with transition-metal-catalyzed couplings.
Application
5-Bromo-7-methylindoline-2,3-dione serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted indole and isoindolinone scaffolds. Its bromo group facilitates palladium-catalyzed cross-coupling reactions, while the electron-deficient dione framework supports nucleophilic additions and cycloadditions. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.
Synthesis
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Route1
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In-stock
1127-59-9 - ~90%
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In-stock
77395-10-9
References
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Montoya-Pelaez, Pedro J.; Uh, Yoon-Seo; Lata, Christopher; Thompson, Matthew P.; Lemieux, Robert P.; Crudden, Cathleen M. Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 5921 - 5929
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Route2
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1189051-96-4 - ~30%
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In-stock
77395-10-9
References
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Soederberg, Bjoern C.G.; Gorugantula, Sobha P.; Howerton, Chet R.; Petersen, Jeffrey L.; Dantale, Shubhada W. Tetrahedron, 2009 , vol. 65, # 36 p. 7357 - 7363
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Route3
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95-53-4
- ~%
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In-stock
77395-10-9
References
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Journal of Medicinal Chemistry, , vol. 50, # 1 p. 21 - 39
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 46.17
- LogP 1.89232
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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