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CS-W001157 4
Total: USD 88.00

5-Bromoindoline-2,3-dione

  • CAS No. 87-48-9

  • Cat. No. CS-W007383
  • Purity≥95%
  • MDL No.MFCD00005719

*For research and further manufacturing use only, not for direct human use.

5-Bromoindoline-2,3-dione|CS-W007383

Structure of 87-48-9

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General Information

  • CAS No. 87-48-9
  • Cat. No. CS-W007383
  • Purity ≥95%
  • MDL No. MFCD00005719
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄BrNO₂
  • Molecular Weight 226.03
  • Synonym(s) 5-Bromoisatin monohydrate; 5-Bromoindoline-2,3-dione
  • SMILES O=C1NC2=C(C=C(Br)C=C2)C1=O

Description

5-Bromoisatin is a 5-haloisatin. One of the methods reported for its synthesis is by reacting N-halosaccharins with isatin in the presence of SiO2. Its inotropic activity has been studied on rhythmically stimulated papillary muscles of guinea pigs. It is reported to exhibit analgesic and sedative properties at a dose of 0.2g/kg in mice.5-Bromoisatin may be used in the synthesis of the following:N-derivatives of 5-bromoisatinN-substituted pyrroleslinear polyaryleneoxindoles5-bromodioxindolecinchoninic acid derivatives3-hydroxyoxindoleS-benzyldithiocarbazate Schiff Bases5-bromooxindoleMorita-Baylis-Hillman adducts of isatin derivatives

Synthesis

  • Route1
    • null|null
      302-17-0
    • null|null
      106-40-1
    • ~65%
    • In-stock
      5-Bromoindoline-2,3-dione|CS-W007383
      87-48-9

    References

    • Liu, Hua-Quan; Wang, De-Cai; Wu, Fei; Tang, Wei; Ouyang, Ping-Kai Chinese Chemical Letters, 2013 , vol. 24, # 10 p. 929 - 933
  • Route2
    • null|null
      66475-83-0
    • ~86%
    • In-stock
      5-Bromoindoline-2,3-dione|CS-W007383
      87-48-9

    References

    • MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael Patent: WO2010/115736 A2, 2010 ; Location in patent: Page/Page column 72 ; WO 2010/115736 A2
  • Route3

    References

    • De Almeida, Leonardo S.; De Mattos, Marcioc. S.; Esteves, Pierre M. Synlett, 2013 , vol. 24, # 5 art. no. ST-2012-S0798-L, p. 603 - 606

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.17
  • LogP   1.5839
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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