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CS-W001157 4
Total: USD 88.00

4-(Chloromethyl)thiazole hydrochloride

  • CAS No. 7709-58-2

  • Cat. No. CS-W010784
  • Purity≥95%
  • MDL No.MFCD02094738
  • HazMat Fee +

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

4-(Chloromethyl)thiazole hydrochloride|CS-W010784

Structure of 7709-58-2

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Description

4-(Chloromethyl)thiazole hydrochloride features a reactive chloromethyl group positioned ortho to the thiazole nitrogen, enabling direct functionalization in late-stage synthesis. This bench-stable salt delivers high reactivity under mild conditions, facilitating efficient coupling with nucleophiles such as amines and thiols. The hydrochloride counterion enhances solubility in polar solvents, streamlining integration into multi-step synthetic sequences for pharmaceutical intermediates and bioconjugation applications.

Application

4-(Chloromethyl)thiazole hydrochloride serves as a versatile building block for constructing thiazole-based heterocycles and bioactive scaffolds. The chloromethyl group enables efficient nucleophilic substitution, facilitating C–C and C–heteroatom bond formation under mild conditions. Its bench-stable solid form simplifies handling and purification, while tolerance to diverse functional groups supports integration into complex synthetic sequences. Widely used in medicinal chemistry and agrochemical research, it functions as a key intermediate in the synthesis of kinase inhibitors and other pharmaceutical candidates.

General Information

  • CAS No. 7709-58-2
  • Cat. No. CS-W010784
  • Purity ≥95%
  • MDL No. MFCD02094738
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅Cl₂NS
  • Molecular Weight 170.06
  • Synonym(s) 4-(CHLOROMETHYL)-1,3-THIAZOLE
  • SMILES ClCC1=CSC=N1.Cl

Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.3037
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group :
Hazard Statements : H302-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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