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CS-W001157 4
Total: USD 88.00

Phenyl carbamate

  • CAS No. 622-46-8

  • Cat. No. CS-0095625
  • Purity≥95%
  • MDL No.MFCD00007961

*For research and further manufacturing use only, not for direct human use.

Phenyl carbamate|CS-0095625

Structure of 622-46-8

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General Information

  • CAS No. 622-46-8
  • Cat. No. CS-0095625
  • Purity ≥95%
  • MDL No. MFCD00007961
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₂
  • Molecular Weight 137.14
  • Synonym(s) Carbamic acid, phenyl ester
  • SMILES NC(OC1=CC=CC=C1)=O

Description

Phenyl carbamate features a stable aryl-carbamate linkage ideal for protecting amine functionalities during synthetic sequences. This bench-stable derivative integrates readily into multi-step syntheses, offering reliable deprotection under mild conditions. Its electron-rich aromatic ring enhances compatibility with diverse reaction environments.

Application

Phenyl carbamate serves as a stable, bench-ready protecting group for primary amines, enabling selective N-protective strategies in peptide synthesis and medicinal chemistry. It facilitates mild deprotection under physiological or basic conditions, offering excellent functional group tolerance and compatibility with diverse reaction environments. Its predictable cleavage profile and ease of purification make it a practical choice for multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • US6525069 B1, ; US 6525069 B1
  • Route2
    • null|null
      143-33-9
    • null|null
      108-95-2
    • ~61%
    • In-stock
      Phenyl carbamate|CS-0095625
      622-46-8

    References

    • Parameswaran; Shi; Klotz Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 936 - 939
  • Route3
    • null|null
      201230-82-2
    • null|null
      98-95-3
    • ~67%
    • In-stock
      Phenyl carbamate|CS-0095625
      622-46-8

    References

    • Lapidus, A. L.; Pirozhkov, S. D.; Antipov, Yu. V. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1983 , vol. 32, # 10 p. 2177 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1983 , # 10 p. 2413

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   1.1441
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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