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CS-W001157 4
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4-(Chloromethyl)thiazol-2-amine hydrochloride

  • CAS No. 59608-97-8

  • Cat. No. CS-W019518
  • Purity≥97%
  • MDL No.MFCD00035215

*For research and further manufacturing use only, not for direct human use.

4-(Chloromethyl)thiazol-2-amine hydrochloride|CS-W019518

Structure of 59608-97-8

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General Information

  • CAS No. 59608-97-8
  • Cat. No. CS-W019518
  • Purity ≥97%
  • MDL No. MFCD00035215
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆Cl₂N₂S
  • Molecular Weight 185.07
  • Synonym(s) 4-(chloromethyl)-1,3-thiazol-2-amine
  • SMILES [H]Cl.NC1=NC(CCl)=CS1

Description

4-(Chloromethyl)thiazol-2-amine hydrochloride features a reactive chloromethyl group flanked by a thiazole ring and a primary amine, enabling efficient conjugation in bioorthogonal workflows. This bench-stable salt form enhances solubility and handling in aqueous reaction media, streamlining incorporation into peptide and small-molecule constructs.

Application

4-(Chloromethyl)thiazol-2-amine hydrochloride serves as a versatile building block for thiazole-based scaffolds, enabling efficient functionalization via nucleophilic substitution. The chloromethyl group facilitates conjugation with amines, thiols, and heterocycles under mild conditions, while the amine functionality offers direct derivatization potential. Bench-stable and compatible with standard purification protocols, it functions effectively in the synthesis of bioactive heterocycles and pharmaceutical intermediates.

Synthesis

  • Route1
    • null|null
      17356-08-0
    • null|null
      534-07-6
    • ~74%
    • In-stock
      4-(Chloromethyl)thiazol-2-amine hydrochloride|CS-W019518
      59608-97-8

    References

    • REPLIDYNE, INC. Patent: WO2009/15193 A1, 2009 ; Location in patent: Page/Page column 44 ; WO 2009/015193 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.8859
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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