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Structure of 7709-58-2
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4-(Chloromethyl)thiazole hydrochloride features a reactive chloromethyl group positioned ortho to the thiazole nitrogen, enabling direct functionalization in late-stage synthesis. This bench-stable salt delivers high reactivity under mild conditions, facilitating efficient coupling with nucleophiles such as amines and thiols. The hydrochloride counterion enhances solubility in polar solvents, streamlining integration into multi-step synthetic sequences for pharmaceutical intermediates and bioconjugation applications.
4-(Chloromethyl)thiazole hydrochloride serves as a versatile building block for constructing thiazole-based heterocycles and bioactive scaffolds. The chloromethyl group enables efficient nucleophilic substitution, facilitating C–C and C–heteroatom bond formation under mild conditions. Its bench-stable solid form simplifies handling and purification, while tolerance to diverse functional groups supports integration into complex synthetic sequences. Widely used in medicinal chemistry and agrochemical research, it functions as a key intermediate in the synthesis of kinase inhibitors and other pharmaceutical candidates.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H318
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: