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CS-W001157 4
Total: USD 88.00

(R)-4-(tert-Butoxy)-3-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid

  • CAS No. 77004-75-2

  • Cat. No. CS-W005550
  • Purity≥97%
  • MDL No.MFCD00236827

*For research and further manufacturing use only, not for direct human use.

(R)-4-(tert-Butoxy)-3-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid|CS-W005550

Structure of 77004-75-2

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General Information

  • CAS No. 77004-75-2
  • Cat. No. CS-W005550
  • Purity ≥97%
  • MDL No. MFCD00236827
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₃NO₆
  • Molecular Weight None
  • Synonym(s) N-Boc-D-aspartic acid 1-(tert-butyl) ester
  • SMILES O=C(C[C@H](C(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)O

Description

(R)-4-(tert-Butoxy)-3-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid is a chiral building block featuring a protected amine and ester functionality, enabling direct incorporation into peptide synthesis workflows. The sterically hindered tert-butyl groups confer enhanced stability under standard reaction conditions.

Application

(R)-4-(tert-Butoxy)-3-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid serves as a key chiral building block for synthesizing γ-lactam-containing scaffolds and peptide mimetics. Its orthogonal protection—tert-butyl ester and Boc-amino groups—enables sequential deprotection and functionalization under standard conditions. The molecule exhibits excellent bench stability and facilitates efficient cyclization to form substituted pyrrolidinones, making it valuable in medicinal chemistry campaigns targeting bioactive heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   101.93
  • LogP   1.6961
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   4

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