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CS-W001157 4
Total: USD 88.00

4-(Pentafluorosulfanyl)aniline

  • CAS No. 2993-24-0

  • Cat. No. CS-W014898
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Pentafluorosulfanyl)aniline|CS-W014898

Structure of 2993-24-0

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General Information

  • CAS No. 2993-24-0
  • Cat. No. CS-W014898
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆F₅NS
  • Molecular Weight 219.18
  • Synonym(s) 4-Aminophenylsulfur Pentafluoride
  • SMILES NC1=CC=C(S(F)(F)(F)(F)F)C=C1

Description

4-(Pentafluorosulfanyl)aniline features a strongly electron-withdrawing pentafluorosulfanyl group positioned para to the aniline nitrogen, imparting enhanced stability and unique electronic properties. This combination enables direct incorporation into functionalized aromatic scaffolds under standard conditions, offering a robust platform for materials science and pharmaceutical development.

Application

4-(Pentafluorosulfanyl)aniline serves as a versatile building block for fluorinated aromatic systems, enabling direct incorporation of the strongly electron-withdrawing -SF₅ group into pharmaceutical and agrochemical scaffolds. Its bench-stable nature and tolerance to common functional groups facilitate use in Suzuki-Miyaura, Buchwald-Hartwig, and nitration reactions. The compound functions as a key intermediate in the synthesis of high-performance materials and bioactive molecules requiring enhanced metabolic stability and lipophilicity.

Synthesis

  • Route1

    References

    • Wang, Chao; Yu, Yan-Bo; Fan, Shilu; Zhang, Xingang Organic Letters, 2013 , vol. 15, # 19 p. 5004 - 5007

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301+H311+H331
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   3.9262
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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