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CS-W001157 4
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3-Amino-5-methylphenol

  • CAS No. 76619-89-1

  • Cat. No. CS-W018778
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Amino-5-methylphenol|CS-W018778

Structure of 76619-89-1

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General Information

  • CAS No. 76619-89-1
  • Cat. No. CS-W018778
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO
  • Molecular Weight 123.15
  • Synonym(s) 5-amino-m-cresol
  • SMILES OC1=CC(C)=CC(N)=C1

Description

3-Amino-5-methylphenol serves as a key building block in the synthesis of advanced organic materials and pharmaceutical intermediates. This electron-rich phenolic compound features a para-oriented amino group flanked by a methyl substituent, enhancing its reactivity in coupling processes. The molecule exhibits excellent stability under standard conditions and integrates readily into complex molecular architectures through selective functionalization pathways.

Application

3-Amino-5-methylphenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling access to substituted heterocycles via straightforward coupling and cyclization reactions. Its ortho-diamine-like reactivity facilitates efficient scaffold construction, while the methyl and hydroxyl groups provide enhanced solubility and directed functionalization. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows.

Synthesis

  • Route1

    References

    • Echavarren, Antonio M.; Tamayo, Nuria; Carmen Paredes Tetrahedron Letters, 1993 , vol. 34, # 29 p. 4713 - 4716
  • Route2

    References

    • Zhurnal Obshchei Khimii, , vol. 22, p. 2019; engl. Ausg. S. 2075
  • Route3
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      618-85-9
    • ~%
    • In-stock
      3-Amino-5-methylphenol|CS-W018778
      76619-89-1

    References

    • J. Gen. Chem. USSR (Engl. Transl.), , vol. 30, # 10 p. 3407 - 3412,3374 - 3379

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.28282
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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