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CS-W001157 4
Total: USD 88.00

3-Methoxy-5-methylbenzenamine

  • CAS No. 66584-31-4

  • Cat. No. CS-W009064
  • Purity≥95%
  • MDL No.MFCD11036303

*For research and further manufacturing use only, not for direct human use.

3-Methoxy-5-methylbenzenamine|CS-W009064

Structure of 66584-31-4

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General Information

  • CAS No. 66584-31-4
  • Cat. No. CS-W009064
  • Purity ≥95%
  • MDL No. MFCD11036303
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁NO
  • Molecular Weight 137.18
  • Synonym(s) 3-Methoxy-5-methylaniline; 3-Methoxy-5-methylphenylamine
  • SMILES NC1=CC(C)=CC(OC)=C1

Description

3-Methoxy-5-methylbenzenamine offers a strategically positioned methoxy group and methyl substituent that enhance electron density at the aromatic ring, facilitating efficient coupling reactions. This bench-stable aniline derivative integrates readily into pharmaceutical intermediates and functional materials where controlled reactivity and solubility are critical.

Application

3-Methoxy-5-methylbenzenamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds and bioactive molecules through standard coupling reactions. Its ortho-directed electrophilic substitution pattern and compatible functional groups facilitate efficient derivatization. The compound exhibits good bench stability and is readily purified by chromatography or recrystallization, making it well-suited for reproducible, scale-up-friendly workflows in API development.

Synthesis

  • Route1

    References

    • Elliott, Eric L.; Bushell, Simon M.; Cavero, Marta; Tolan, Brian; Kelly, T. Ross Organic Letters, 2005 , vol. 7, # 12 p. 2449 - 2451
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    • In-stock
      3-Methoxy-5-methylbenzenamine|CS-W009064
      66584-31-4

    References

    • Organic Letters, , vol. 7, # 12 p. 2449 - 2451
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      618-85-9
    • ~%
    • In-stock
      3-Methoxy-5-methylbenzenamine|CS-W009064
      66584-31-4

    References

    • Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 829 - 831

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.58582
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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