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CS-W001157 4
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3-Amino-5-chlorophenol

  • CAS No. 883195-40-2

  • Cat. No. CS-0113697
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Amino-5-chlorophenol|CS-0113697

Structure of 883195-40-2

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General Information

  • CAS No. 883195-40-2
  • Cat. No. CS-0113697
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClNO
  • Molecular Weight 143.57
  • Synonym(s) 3-Amino-5-chlor-phenol
  • SMILES OC1=CC(Cl)=CC(N)=C1

Description

3-Amino-5-chlorophenol delivers a reactive amino group positioned ortho to a phenolic hydroxyl, flanked by a chloro substituent at the para position. This arrangement enables direct incorporation into coupling reactions, offering enhanced solubility and stability under standard bench conditions for synthesis of functionalized intermediates in pharmaceutical and agrochemical development.

Application

3-Amino-5-chlorophenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted heterocycles and aromatic scaffolds. Its ortho-directed reactivity facilitates electrophilic substitution and coupling reactions, while the amino and phenolic functionalities offer complementary handles for derivatization. The compound exhibits good bench stability and is readily purified by recrystallization or column chromatography, supporting its use in multi-step syntheses and process development.

Synthesis

  • Route1

    References

    • BAYER HEALTHCARE AG Patent: WO2009/33581 A1, 2009 ; Location in patent: Page/Page column 95-96 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.6278
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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