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CS-W001157 4
Total: USD 88.00

N,N-Dibutylformamide

  • CAS No. 761-65-9

  • Cat. No. CS-0187560
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N,N-Dibutylformamide|CS-0187560

Structure of 761-65-9

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General Information

  • CAS No. 761-65-9
  • Cat. No. CS-0187560
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₉NO
  • Molecular Weight 157.25
  • Synonym(s) N,N-Di-n-butylformamide
  • SMILES CCCCN(CCCC)C=O

Description

N,N-Dibutylformamide is a polar, bench-stable amide solvent featuring two butyl chains that enhance solubility in nonpolar media. This structure delivers high thermal stability and low viscosity, enabling efficient reaction mixing. It serves as a robust alternative to dimethylformamide in sensitive coupling protocols, offering reduced nucleophilicity while maintaining excellent compatibility with organometallic reagents.

Application

N,N-Dibutylformamide serves as a stable, bench-ready amide reagent enabling efficient formylation reactions under mild conditions. Its tertiary amide structure provides excellent functional group tolerance and ease of purification, making it well-suited for use in peptide synthesis and the construction of heterocyclic scaffolds. The molecule functions as a versatile formylating agent in both stoichiometric and catalytic transformations.

Synthesis

  • Route1
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      102-82-9
    • ~%
    • In-stock
      N,N-Dibutylformamide|CS-0187560
      761-65-9

    References

    • Justus Liebigs Annalen der Chemie, , vol. 582, p. 1,13, 31
  • Route2
    • null|null
      111-92-2
    • ~%
    • In-stock
      N,N-Dibutylformamide|CS-0187560
      761-65-9

    References

    • Justus Liebigs Annalen der Chemie, , vol. 582, p. 1,13, 31
  • Route3
    • null|null
      77287-34-4
    • null|null
      71-36-3
    • ~17%
    • null|null
      871-71-6
    • In-stock
      N,N-Dibutylformamide|CS-0187560
      761-65-9

    References

    • Bulletin of the Chemical Society of Japan, , vol. 56, # 9 p. 2647 - 2651

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317-H412
Precautionary Statements : P261-P272-P273-P280-P302+P352-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   2.045
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   7

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