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CS-W001157 4
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N,N-Dipropylformamide

  • CAS No. 6282-00-4

  • Cat. No. CS-W011117
  • Purity≥98%
  • MDL No.MFCD00043518

*For research and further manufacturing use only, not for direct human use.

N,N-Dipropylformamide|CS-W011117

Structure of 6282-00-4

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General Information

  • CAS No. 6282-00-4
  • Cat. No. CS-W011117
  • Purity ≥98%
  • MDL No. MFCD00043518
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅NO
  • Molecular Weight 129.20
  • Synonym(s) NN-Dipropylformamide
  • SMILES O=CN(CCC)CCC

Description

N,N-Dipropylformamide is a polar aprotic solvent featuring two propyl chains attached to the nitrogen of the formamide core. This structure imparts enhanced solubility for organic and organometallic compounds, along with improved thermal and hydrolytic stability under standard conditions. It serves as a robust alternative in synthetic transformations requiring minimal nucleophilicity and high compatibility with sensitive reaction intermediates.

Application

N,N-Dipropylformamide serves as a stable, polar aprotic solvent and versatile amide coupling reagent in synthetic organic chemistry. It facilitates efficient reactions in nucleophilic substitutions and enolate alkylations, offering excellent solubility for both organic substrates and inorganic salts. Its bench-stable nature and low volatility enhance handling safety and reproducibility in multi-step syntheses.

Synthesis

  • Route1
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      64-18-6
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      142-84-7
    • ~84%
    • In-stock
      N,N-Dipropylformamide|CS-W011117
      6282-00-4

    References

    • Pathare, Sagar P.; Sawant, Ravindra V.; Akamanchi, Krishnacharya G. Tetrahedron Letters, 2012 , vol. 53, # 26 p. 3259 - 3263
  • Route2
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      124-38-9
    • null|null
      142-84-7
    • ~%
    • In-stock
      N,N-Dipropylformamide|CS-W011117
      6282-00-4

    References

    • Chemical Communications, , # 5 p. 433 - 434
  • Route3
    • null|null
      201230-82-2
    • null|null
      142-84-7
    • ~%
    • In-stock
      N,N-Dipropylformamide|CS-W011117
      6282-00-4

    References

    • Journal of Organometallic Chemistry, , vol. 330, p. 429 - 436

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   1.2648
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   5

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