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CS-W001157 4
Total: USD 88.00

5-Methyl-1H-indazol-6-amine

  • CAS No. 75844-28-9

  • Cat. No. CS-0131004
  • Purity≥95%
  • MDL No.MFCD09880182

*For research and further manufacturing use only, not for direct human use.

5-Methyl-1H-indazol-6-amine|CS-0131004

Structure of 75844-28-9

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General Information

  • CAS No. 75844-28-9
  • Cat. No. CS-0131004
  • Purity ≥95%
  • MDL No. MFCD09880182
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉N₃
  • Molecular Weight 147.18
  • Synonym(s) 6-AMINO-5-METHYLINDOLE
  • SMILES NC1=CC2=C(C=C1C)C=NN2

Description

5-Methyl-1H-indazol-6-amine features a fused bicyclic indazole core with a methyl group at the 5-position and a primary amine at the 6-position. This scaffold delivers enhanced electron density and improved solubility in polar solvents, enabling efficient incorporation into pharmaceutical intermediates and bioactive molecule libraries.

Application

5-Methyl-1H-indazol-6-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds through palladium-catalyzed cross-coupling and electrophilic substitution reactions. Its ortho-amino functionality facilitates direct functionalization, while the methyl group enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability and is compatible with standard purification protocols, making it ideal for iterative library synthesis and API development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.45352
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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