N6-Butyryl-L-lysine

Name: N6-Butyryl-L-lysine
Brand: ChemScene
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CAS No. 75396-30-4
Cat. No. CS-0100615
Purity≥97%
MDL No.MFCD29076248

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 75396-30-4
Cat. No. CS-0100615
Purity ≥97%
MDL No. MFCD29076248
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₀N₂O₃
Molecular Weight 216.28
Synonym(s) None
SMILES N[C@@H](CCCCNC(CCC)=O)C(O)=O

Description

N6-Butyryl-L-lysine is a synthetic lysine derivative featuring a butyryl group attached to the ε-amino side chain. This modification enhances hydrophobicity and stability, enabling direct incorporation into peptide sequences for epigenetic studies. The acyl moiety resists spontaneous deacylation under physiological conditions, supporting reliable histone mimicry in biochemical assays.

Application

N6-Butyryl-L-lysine serves as a well-defined lysine acylation derivative, enabling site-specific modification in peptide synthesis and epigenetic studies. Its butyryl group provides enhanced hydrophobicity and metabolic stability compared to acetyl or propionyl analogs, facilitating improved membrane permeability in bioactive peptides. The compound exhibits excellent bench stability and compatibility with standard Fmoc-based solid-phase peptide synthesis protocols, allowing straightforward incorporation into complex sequences.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 92.42
LogP 0.4849
H_Acceptors 3
H_Donors 3
Rotatable_Bonds 8

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Lysine and derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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N6-Butyryl-L-lysine

CAS No. 75396-30-4

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