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CS-W001157 4
Total: USD 88.00

1-Boc-4-(4-aminobutyl)piperazine

  • CAS No. 745048-07-1

  • Cat. No. CS-0038081
  • Purity≥95%
  • MDL No.MFCD04038543

*For research and further manufacturing use only, not for direct human use.

1-Boc-4-(4-aminobutyl)piperazine|CS-0038081

Structure of 745048-07-1

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General Information

  • CAS No. 745048-07-1
  • Cat. No. CS-0038081
  • Purity ≥95%
  • MDL No. MFCD04038543
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₇N₃O₂
  • Molecular Weight 257.37
  • Synonym(s) None
  • SMILES CC(C)(C)OC(=O)N1CCN(CCCCN)CC1

Description

tert-Butyl 4-(4-aminobutyl)piperazine-1-carboxylate features a piperazine core functionalized with a butylamine chain and a bench-stable tert-butyl ester. This protected amine derivative integrates seamlessly into peptide coupling workflows, enabling efficient access to complex piperazine-based scaffolds in medicinal chemistry and chemical biology applications.

Application

tert-Butyl 4-(4-aminobutyl)piperazine-1-carboxylate serves as a versatile bifunctional building block for medicinal chemistry and process development. The piperazine core provides a rigid, polar scaffold ideal for modulating solubility and bioavailability, while the protected amine enables straightforward derivatization via standard coupling reactions. The tert-butyl carbamate group offers excellent bench stability and facile removal under mild acidic conditions, facilitating late-stage functionalization in API synthesis.

Synthesis

  • Route1
    • null|null
      745048-06-0
    • ~98%
    • In-stock
      1-Boc-4-(4-aminobutyl)piperazine|CS-0038081
      745048-07-1

    References

    • GE HEALTHCARE LIMITED; MEDI-PHYSICS, INC.; NEWINGTON, Ian, Martin; WYNN, Duncan George; NAIRNE, Robert James Domett; GUILBERT, Benedicte; MANDAL, Subrata; JINTO, Jose; VARADARAJAN, Sunderaraman; RANGASWAMY, Chitralekha; BETTS, Helen; DAVIS, Rebecca Patent: WO2011/150183 A1, 2011 ; Location in patent: Page/Page column 170; 172 ; WO 2011/150183 A1
  • Route2
    • N-Boc-piperazine Olaparib Impurity|CS-0214004
      57260-71-6
    • ~%
    • In-stock
      1-Boc-4-(4-aminobutyl)piperazine|CS-0038081
      745048-07-1

    References

    • Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
  • Route3

    References

    • Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P280-P302+P352-P304+P340-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.8
  • LogP   1.278
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   4

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