tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate

Name: tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 373608-48-1
Cat. No. CS-0039166
Purity≥97%
MDL No.MFCD06808578

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate|CS-0039166

Structure of 373608-48-1

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General Information

CAS No. 373608-48-1
Cat. No. CS-0039166
Purity ≥97%
MDL No. MFCD06808578
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₅N₃O₂
Molecular Weight 243.35
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1CCN(CC1)CCCN

Description

tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate features a piperazine core functionalized with a primary amine-bearing propyl chain and a robust tert-butyl carbamate protecting group. This combination enables straightforward deprotection under mild acidic conditions while maintaining stability during synthetic manipulations. The molecule integrates readily into diverse scaffolds for medicinal chemistry applications, particularly in the development of targeted small-molecule probes and bioactive compounds.

Application

tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate serves as a versatile bifunctional building block for medicinal chemistry and peptide conjugation. The piperazine core enables hydrogen bonding and solubility enhancement, while the primary amine and tert-butyl carbamate groups offer orthogonal reactivity for sequential functionalization. It facilitates rapid access to complex heterocyclic scaffolds and is compatible with standard coupling protocols, purification by chromatography, and bench-stable handling under ambient conditions.

Synthesis

Route1
- 857266-28-5
- ~%
- In-stock
  
  373608-48-1
References
- WO2005/60970 A1, ; Page/Page column 138 ; WO 2005/060970 A1
Route2
- 946517-70-0
- 603-35-0
- ~93%
- In-stock
  
  373608-48-1
References
- US2008/306082 A1, ; Page/Page column 4-5 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 58.8
LogP 0.8879
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Boc

Building Blocks Functional Group Amine

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

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tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate

CAS No. 373608-48-1

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