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CS-W001157 4
Total: USD 88.00

1-(3-Aminopropyl)-4-methylpiperazine

  • CAS No. 4572-03-6

  • Cat. No. CS-0033789
  • Purity≥97%
  • MDL No.MFCD00014616

*For research and further manufacturing use only, not for direct human use.

1-(3-Aminopropyl)-4-methylpiperazine|CS-0033789

Structure of 4572-03-6

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General Information

  • CAS No. 4572-03-6
  • Cat. No. CS-0033789
  • Purity ≥97%
  • MDL No. MFCD00014616
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₉N₃
  • Molecular Weight 157.26
  • Synonym(s) None
  • SMILES NCCCN1CCN(C)CC1

Description

3-(4-Methylpiperazin-1-yl)propan-1-amine features a flexible alkyl chain linking a piperazine ring with a methyl substituent, enabling strong coordination in metal complexation and enhanced solubility in polar solvents. This amine integrates readily into ligand architectures for catalysis and bioconjugation applications.

Application

3-(4-Methylpiperazin-1-yl)propan-1-amine serves as a versatile bifunctional building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds and bioactive molecules. Its primary amine functionality facilitates conjugation and derivatization, while the piperazine ring offers enhanced solubility and metabolic stability. The molecule exhibits good bench stability and compatibility with standard coupling protocols, making it well-suited for modular synthesis and library generation.

Synthesis

  • Route1
    • 3-(4-Methylpiperazin-1-yl)propanenitrile|CS-0179159
      4491-92-3
    • ~40%
    • In-stock
      1-(3-Aminopropyl)-4-methylpiperazine|CS-0033789
      4572-03-6

    References

    • Synthesis (Germany), , vol. 45, # 1 art. no. SS-2012-H0716-OP, p. 45 - 52
  • Route2
    • null|null
      6820-96-8
    • ~37%
    • In-stock
      1-(3-Aminopropyl)-4-methylpiperazine|CS-0033789
      4572-03-6

    References

    • Journal of Medicinal Chemistry, , vol. 51, # 17 p. 5264 - 5270
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 13 p. 2131 - 2135

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   32.5
  • LogP   -0.4174
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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