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3-(Piperidin-1-yl)propan-1-amine

  • CAS No. 3529-08-6

  • Cat. No. CS-0105129
  • Purity≥95%
  • MDL No.MFCD27756345

*For research and further manufacturing use only, not for direct human use.

3-(Piperidin-1-yl)propan-1-amine|CS-0105129

Structure of 3529-08-6

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General Information

  • CAS No. 3529-08-6
  • Cat. No. CS-0105129
  • Purity ≥95%
  • MDL No. MFCD27756345
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₈N₂
  • Molecular Weight 142.24
  • Synonym(s) N-AMINOPROPYL PIPERIDINE
  • SMILES NCCCN1CCCCC1

Application

3-(Piperidin-1-yl)propan-1-amine serves as a versatile bifunctional building block in medicinal chemistry, enabling the construction of complex heterocyclic scaffolds and peptide-like architectures. Its pendant amine and piperidine ring offer complementary reactivity for conjugation, derivatization, and metal coordination. The compound exhibits excellent bench stability, facilitates straightforward purification via salt formation, and demonstrates broad functional group tolerance in standard coupling and alkylation protocols.

Synthesis

  • Route1

    References

    • Kumar, Versha Vinay; Singh, Sudhir K.; Sharma; Bhaduri; Gupta, Suman; Zaidi, Alima; Tiwari, Suman; Katiyar Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 6 p. 675 - 680
  • Route2
    • null|null
      4733-45-3
    • ~73%
    • In-stock
      3-(Piperidin-1-yl)propan-1-amine|CS-0105129
      3529-08-6

    References

    • Lavrado, Joao; Cabal, Ghislain G.; Prudencio, Miguel; Mota, Maria M.; Gut, Jiri; Rosenthal, Philip J.; Diaz, Cecilia; Guedes, Rita C.; Dos Santos, Daniel J. V. A.; Bichenkovss, Elena; Douglas, Kenneth T.; Moreira, Rui; Paulo, Alexandra Journal of Medicinal Chemistry, 2011 , vol. 54, # 3 p. 734 - 750
  • Route3
    • null|null
      76439-26-4
    • ~%
    • In-stock
      3-(Piperidin-1-yl)propan-1-amine|CS-0105129
      3529-08-6

    References

    • Journal of the American Chemical Society, , vol. 74, p. 2016 US2540938 , ; US2652430 , ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H302-H314
Precautionary Statements : P210-P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   0.8211
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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