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CS-W001157 4
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tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate

  • CAS No. 874831-60-4

  • Cat. No. CS-0129024
  • Purity≥95%
  • MDL No.MFCD06808577

*For research and further manufacturing use only, not for direct human use.

tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate|CS-0129024

Structure of 874831-60-4

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General Information

  • CAS No. 874831-60-4
  • Cat. No. CS-0129024
  • Purity ≥95%
  • MDL No. MFCD06808577
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₅N₃O₂
  • Molecular Weight 243.35
  • Synonym(s) None
  • SMILES O=C(NCCCN1CCNCC1)OC(C)(C)C

Description

tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate delivers a protected piperazinyl-propyl scaffold ideal for late-stage functionalization in peptide and small-molecule synthesis. This bench-stable carbamate integrates readily into complex architectures, offering enhanced solubility and compatibility with diverse reaction conditions.

Application

tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate serves as a versatile bifunctional building block, enabling efficient introduction of both piperazinyl and protected amine moieties in synthetic sequences. The tert-butyl carbamate group offers excellent bench stability and orthogonal deprotection under mild acidic conditions, while the piperazinyl side chain provides a readily accessible nitrogen-rich scaffold for diversification. This compound facilitates straightforward incorporation into bioactive molecules, particularly in medicinal chemistry campaigns requiring solubility-enhancing heterocycles and modular amine coupling.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   53.6
  • LogP   0.8064
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   4

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