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CS-W001157 4
Total: USD 88.00

1H-Imidazo[4,5-c]pyridin-2(3H)-one

  • CAS No. 7397-68-4

  • Cat. No. CS-W021327
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1H-Imidazo[4,5-c]pyridin-2(3H)-one|CS-W021327

Structure of 7397-68-4

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General Information

  • CAS No. 7397-68-4
  • Cat. No. CS-W021327
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅N₃O
  • Molecular Weight 135.12
  • Synonym(s) 1,3-DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE
  • SMILES O=C(N1)NC2=C1C=CN=C2

Description

1H-Imidazo[4,5-c]pyridin-2(3H)-one is a heterocyclic scaffold featuring a fused imidazole-pyridine core with intrinsic electron-deficient character. This rigid, planar structure enhances π-stacking interactions and confers stability under standard conditions. The lactam functionality enables hydrogen bonding and facilitates incorporation into bioactive molecules. It serves as a privileged motif in medicinal chemistry for targeting protein-protein interactions and kinase inhibition.

Application

1H-Imidazo[4,5-c]pyridin-2(3H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its fused tricyclic structure exhibits robust bench stability and facilitates diverse functionalization at the C1, C4, and C7 positions. The compound functions effectively in transition-metal-catalyzed coupling reactions and serves as a key intermediate in the synthesis of kinase inhibitors and other pharmaceutical candidates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   61.54
  • LogP   0.2512
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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