Lot numbers can be found on the outside label of a product:
Oxazolo[4,5-b]pyridin-2(3H)-one
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CAS No. 60832-72-6
- Cat. No. CS-0012220
- Purity≥98%
- MDL No.MFCD00204215
*For research and further manufacturing use only, not for direct human use.
![Oxazolo[4,5-b]pyridin-2(3H)-one|CS-0012220](https://file.chemscene.com/productPIC/CS-0012220.gif)
Structure of 60832-72-6
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General Information
- CAS No. 60832-72-6
- Cat. No. CS-0012220
- Purity ≥98%
- MDL No. MFCD00204215
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₄N₂O₂
- Molecular Weight 136.11
- Synonym(s) Oxazol[4,5-b]pyridine-2(3h)one
- SMILES O=C1OC2=CC=CN=C2N1
Description
Oxazolo[4,5-b]pyridin-2(3H)-one is a heterocyclic scaffold featuring a fused oxazole-pyridinone core with inherent hydrogen-bonding capacity. This electron-deficient system enables robust integration into bioactive molecules, particularly as a privileged structure in kinase inhibitors and medicinal chemistry campaigns requiring metabolic stability and precise target engagement.
Application
Oxazolo[4,5-b]pyridin-2(3H)-one serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling efficient construction of bioactive molecules. Its fused oxazole-pyridinone core exhibits favorable stability, moderate basicity, and compatibility with diverse functional groups, facilitating downstream derivatization via nucleophilic substitution or transition-metal-catalyzed coupling. The compound functions effectively as a building block for kinase inhibitors and other targeted therapeutics, offering predictable reactivity and ease of purification in standard synthetic workflows.
Synthesis
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Route1
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In-stock
15128-82-2 -
201230-82-2 - ~59%
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In-stock
60832-72-6
References
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Wang, Xiaofang; Ling, Gang; Xue, Yan; Lu, Shiwei European Journal of Organic Chemistry, 2005 , # 8 p. 1675 - 1679
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Route2
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In-stock
933-90-4 - ~67%
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In-stock
60832-72-6
References
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Prakash; Batra; Kaur; Sharma; Singh; Moriarty Synthesis, 2001 , # 4 p. 541 - 543
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Route3
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In-stock
16867-03-1 -
32315-10-9
- ~87%
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In-stock
60832-72-6
References
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Qian, Jian-Qiang; Yan, Pu-Cha; Che, Da-Qing; Zhou, Qi-Lin; Li, Yuan-Qiang Tetrahedron Letters, 2014 , vol. 55, # 9 p. 1528 - 1531
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 58.89
- LogP 0.5161
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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