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CS-W001157 4
Total: USD 88.00

(4-Aminophenyl)dimethylphosphine oxide

  • CAS No. 737751-54-1

  • Cat. No. CS-0112141
  • Purity≥95%
  • MDL No.MFCD20696907

*For research and further manufacturing use only, not for direct human use.

(4-Aminophenyl)dimethylphosphine oxide|CS-0112141

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General Information

  • CAS No. 737751-54-1
  • Cat. No. CS-0112141
  • Purity ≥95%
  • MDL No. MFCD20696907
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂NOP
  • Molecular Weight 169.16
  • Synonym(s) 4-(dimethylphosphoryl)aniline
  • SMILES CP(C)(C1=CC=C(N)C=C1)=O

Description

(4-Aminophenyl)dimethylphosphine oxide features a phosphine oxide moiety appended to an electron-rich aniline scaffold, enabling robust coordination in catalytic systems. This bench-stable, moisture-tolerant ligand integrates seamlessly into transition metal complexes, delivering enhanced reactivity and selectivity in cross-coupling transformations.

Application

(4-Aminophenyl)dimethylphosphine oxide serves as a versatile phosphine-based building block in synthetic organic chemistry, enabling efficient transition metal-catalyzed cross-coupling reactions. Its amine-functionalized aryl group provides enhanced solubility and coordination ability, while the dimethylphosphine oxide moiety offers robust stability and compatibility with diverse reaction conditions. The molecule facilitates C–C and C–heteroatom bond formation under mild catalytic systems, making it a practical reagent for constructing functionalized biaryls and pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   1.5168
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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