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CS-W001157 4
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2-Iodo-1-(2,2,2-trifluoroethyl)-1H-indol-4-amine

  • CAS No. 2127096-38-0

  • Cat. No. CS-0527832
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Iodo-1-(2,2,2-trifluoroethyl)-1H-indol-4-amine|CS-0527832

Structure of 2127096-38-0

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General Information

  • CAS No. 2127096-38-0
  • Cat. No. CS-0527832
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈F₃IN₂
  • Molecular Weight 340.09
  • Synonym(s) None
  • SMILES NC1=CC=CC2=C1C=C(I)N2CC(F)(F)F

Description

This indole derivative features a trifluoroethyl group enhancing metabolic stability and a reactive iodo substituent enabling efficient cross-coupling. The electron-rich indol-4-amine core supports diverse functionalization, while the pendant amine facilitates conjugation or salt formation. Designed for medicinal chemistry applications requiring robustness under standard conditions.

Application

2-Iodo-1-(2,2,2-trifluoroethyl)-1H-indol-4-amine serves as a versatile building block for the construction of functionalized indole scaffolds in medicinal chemistry. The iodide group enables palladium-catalyzed cross-coupling reactions, while the trifluoroethyl moiety enhances metabolic stability and modulates lipophilicity. This compound exhibits good bench stability and facilitates efficient incorporation into complex molecular architectures via standard coupling protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   30.95
  • LogP   3.3904
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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