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CS-W001157 4
Total: USD 88.00

4-(Hydroxymethyl)phenylacetic acid

  • CAS No. 73401-74-8

  • Cat. No. CS-W004128
  • Purity≥97%
  • MDL No.MFCD00065692

*For research and further manufacturing use only, not for direct human use.

4-(Hydroxymethyl)phenylacetic acid|CS-W004128

Structure of 73401-74-8

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General Information

  • CAS No. 73401-74-8
  • Cat. No. CS-W004128
  • Purity ≥97%
  • MDL No. MFCD00065692
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₃
  • Molecular Weight 166.18
  • Synonym(s) 4HMPAA
  • SMILES O=C(CC1=CC=C(CO)C=C1)O

Description

4-(Hydroxymethyl)phenylacetic acid features a hydroxymethyl group flanking a phenylacetic core, enabling facile derivatization and integration into bioconjugation workflows. This bench-stable, moisture-tolerant reagent delivers enhanced solubility in aqueous-organic mixtures, streamlining purification and handling during synthetic and analytical applications.

Application

4-(Hydroxymethyl)phenylacetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive molecules via established coupling and functional group transformation protocols. Its phenylacetic core provides structural rigidity and metabolic stability, while the pendant hydroxymethyl group offers a handle for derivatization—facilitating conjugation, protection, or further functionalization. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • null|null
      13737-36-5
    • ~53%
    • In-stock
      4-(Hydroxymethyl)phenylacetic acid|CS-W004128
      73401-74-8

    References

    • Sankyo Company, Limited Patent: US5534529 A1, 1996 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   0.806
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   3

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