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CS-W001157 4
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1-Bromo-3-methoxypropane

  • CAS No. 36865-41-5

  • Cat. No. CS-W010945
  • Purity≥97%
  • MDL No.MFCD02258473

*For research and further manufacturing use only, not for direct human use.

1-Bromo-3-methoxypropane|CS-W010945

Structure of 36865-41-5

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General Information

  • CAS No. 36865-41-5
  • Cat. No. CS-W010945
  • Purity ≥97%
  • MDL No. MFCD02258473
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉BrO
  • Molecular Weight 153.02
  • Synonym(s) Propane, 1-bromo-3-methoxy-; 1-Bromo-3-methoxypropane
  • SMILES BrCCCOC

Description

1-Bromo-3-methoxypropane serves as a versatile bifunctional reagent, combining a reactive bromide handle with a stable methoxy group. This structure enables selective alkylation in synthetic transformations, particularly in the construction of ether linkages and functionalized polymers. The molecule exhibits favorable stability under standard conditions, facilitating straightforward handling in process development workflows.

Application

1-Bromo-3-methoxypropane serves as a versatile bifunctional building block in synthetic organic chemistry, enabling efficient ether and amine functionalization. Its terminal bromide facilitates nucleophilic substitution reactions with amines, thiols, and carbanions, while the methoxy group provides stability and polarity. The molecule exhibits excellent bench stability and compatibility with common protecting group strategies, making it ideal for constructing heterocyclic scaffolds and bioactive intermediates in medicinal chemistry workflows.

Synthesis

  • Route1
    • null|null
      1589-49-7
    • ~50%
    • In-stock
      1-Bromo-3-methoxypropane|CS-W010945
      36865-41-5

    References

    • Heathcock, Clayton H.; Kleinman, Edward F.; Binkley, Edward S. Journal of the American Chemical Society, 1982 , vol. 104, # 4 p. 1054 - 1068
  • Route2
    • null|null
      186581-53-3
    • In-stock
      3-Bromopropan-1-ol|CS-W007337
      627-18-9
    • ~21%
    • In-stock
      1-Bromo-3-methoxypropane|CS-W010945
      36865-41-5

    References

    • Vodovozova, E. L.; Mikhalev, I. I.; Rzhaninova, A. A.; Garaev, M. M.; Molotkovsky, Yul. G. Russian Journal of Bioorganic Chemistry, 1995 , vol. 21, # 9 p. 626 - 632 Bioorganicheskaya Khimiya, 1995 , vol. 21, # 9 p. 724 - 730
  • Route3
    • null|null
      420-37-1
    • In-stock
      3-Bromopropan-1-ol|CS-W007337
      627-18-9
    • ~56%
    • In-stock
      1-Bromo-3-methoxypropane|CS-W010945
      36865-41-5

    References

    • Grob, Cyril A.; Waldner, Adrian Helvetica Chimica Acta, 1980 , vol. 63, # 8 p. 2152 - 2158

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P362-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   1.4178
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

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