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CS-W001157 4
Total: USD 88.00

3,5-Difluoropyridin-2-ylamine

  • CAS No. 732306-31-9

  • Cat. No. CS-0059236
  • Purity≥97%
  • MDL No.MFCD03788760

*For research and further manufacturing use only, not for direct human use.

3,5-Difluoropyridin-2-ylamine|CS-0059236

Structure of 732306-31-9

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General Information

  • CAS No. 732306-31-9
  • Cat. No. CS-0059236
  • Purity ≥97%
  • MDL No. MFCD03788760
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄F₂N₂
  • Molecular Weight 130.10
  • Synonym(s) 3,5-Difluoro-2-pyridinamine
  • SMILES NC1=NC=C(F)C=C1F

Description

3,5-Difluoropyridin-2-ylamine features a pyridine ring bearing two fluorine atoms at the 3 and 5 positions, enhancing electron-withdrawal and metabolic stability. The primary amine group enables direct coupling in cross-coupling reactions and facilitates incorporation into pharmaceutical scaffolds. This bench-stable, moisture-tolerant reagent serves as a key building block for targeted medicinal chemistry campaigns.

Application

3,5-Difluoropyridin-2-ylamine serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its difluoropyridine core facilitates nucleophilic substitution and transition-metal-catalyzed coupling reactions. The amine functionality offers direct handle for derivatization, while the fluorine substituents enhance metabolic stability and modulate electronic properties. Bench-stable and readily purified, it functions effectively in standard synthetic workflows for API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.942
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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