4,5-Difluoropyridin-2-amine

Name: 4,5-Difluoropyridin-2-amine
Brand: ChemScene
Availability: InStock
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CAS No. 1211537-08-4
Cat. No. CS-0130943
Purity≥98%
MDL No.MFCD18259315

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 1211537-08-4

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General Information

CAS No. 1211537-08-4
Cat. No. CS-0130943
Purity ≥98%
MDL No. MFCD18259315
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄F₂N₂
Molecular Weight 130.10
Synonym(s) 2-AMino-4,5-difluoropyridine
SMILES NC1=NC=C(F)C(F)=C1

Description

4,5-Difluoropyridin-2-amine is a bench-stable, electron-deficient heterocycle featuring two fluorine atoms at the 4- and 5-positions, enabling selective coupling reactions. The ortho-amino group facilitates direct functionalization in C–N bond formation, offering high reactivity under mild conditions. This scaffold integrates readily into pharmaceutical intermediates and agrochemicals.

Application

4,5-Difluoropyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 3-position via nucleophilic substitution due to the activating effect of the amino group and the electron-withdrawing fluorine atoms. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient synthesis of substituted pyridines and heterocyclic scaffolds relevant to pharmaceutical development.

Synthesis

Route1
- 1428262-95-6
- ~%
- In-stock
  
  1211537-08-4
References
- MERCK SHARP and DOHME CORP.; BENNETT, D. Jonathan; CAI, Jaiqiang; CARSWELL, Emma; COOKE, Andrew; HOYT, Scott, B.; LONDON, Clare; MACLEAN, John; RATCLIFFE, Paul; TAYLOR, Jerry Andrew; XIONG, Yusheng; SAMANTA, Swapan Kumar; KULKARNI, Bheemashankar, A. Patent: WO2013/43520 A1, 2013 ; Location in patent: Paragraph 54 ;
Route2
- In-stock
  
  944401-77-8
- ~%
- In-stock
  
  1211537-08-4
References
- MERCK SHARP and DOHME CORP.; BENNETT, D. Jonathan; CAI, Jaiqiang; CARSWELL, Emma; COOKE, Andrew; HOYT, Scott, B.; LONDON, Clare; MACLEAN, John; RATCLIFFE, Paul; TAYLOR, Jerry Andrew; XIONG, Yusheng; SAMANTA, Swapan Kumar; KULKARNI, Bheemashankar, A. Patent: WO2013/43520 A1, 2013 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 38.91
LogP 0.942
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4,5-Difluoropyridin-2-amine

CAS No. 1211537-08-4

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