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CS-W001157 4
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tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate

  • CAS No. 723286-79-1

  • Cat. No. CS-W000013
  • Purity≥97%
  • MDL No.MFCD10574958

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate|CS-W000013

Structure of 723286-79-1

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General Information

  • CAS No. 723286-79-1
  • Cat. No. CS-W000013
  • Purity ≥97%
  • MDL No. MFCD10574958
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₆N₄O₂
  • Molecular Weight 224.26
  • Synonym(s) 5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER
  • SMILES CC(C)(C)OC(=O)N1CCn2cnnc2C1

Description

tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate is a bench-stable heterocyclic building block featuring a fused triazolopyrazine core. This nitrogen-rich scaffold integrates readily into medicinal chemistry campaigns, offering enhanced solubility and metabolic stability in lead optimization workflows.

Application

tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate serves as a versatile heterocyclic building block for the synthesis of triazolopyrazine scaffolds. Its tert-butyl ester group enables facile deprotection under mild acidic conditions, while the dihydro core supports selective functionalization and transition-metal-catalyzed coupling reactions. The molecule exhibits good bench stability and compatibility with common protecting group strategies, facilitating its use in medicinal chemistry campaigns targeting kinase inhibitors and other bioactive compounds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.25
  • LogP   1.0288
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   0

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