Lot numbers can be found on the outside label of a product:
8-Bromochroman-4-one
-
CAS No. 204377-88-8
- Cat. No. CS-0033201
- Purity≥97%
- MDL No.MFCD09744046
*For research and further manufacturing use only, not for direct human use.
Structure of 204377-88-8
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 204377-88-8
- Cat. No. CS-0033201
- Purity ≥97%
- MDL No. MFCD09744046
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₇BrO₂
- Molecular Weight 227.05
- Synonym(s) 4H-1-benzopyran-4-one, 8-bromo-2,3-dihydro-
- SMILES BrC1=C2C(C(CCO2)=O)=CC=C1
Description
8-Bromochroman-4-one is a brominated chromanone derivative featuring a reactive ketone at the 4-position and a bromine substituent at the 8-position. This structural combination enables direct functionalization in cross-coupling reactions and facilitates downstream derivatization in medicinal chemistry. The molecule exhibits enhanced electrophilicity at the carbonyl carbon and improved solubility in polar organic solvents, streamlining its integration into synthetic workflows.
Application
8-Bromochroman-4-one serves as a versatile building block in medicinal chemistry, enabling late-stage functionalization and transition-metal-catalyzed cross-coupling reactions. Its bromine substituent at the C8 position provides high reactivity in Pd-mediated transformations, while the chroman-4-one core offers structural rigidity and compatibility with diverse synthetic manipulations. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for iterative synthesis workflows in API development.
Synthesis
-
Route1
-
1403387-58-5 - ~48%
-
In-stock
204377-88-8
References
-
PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas Patent: WO2012/139775 A1, 2012 ; Location in patent: Page/Page column 60-61 ; WO 2012/139775 A1
-
-
Route2
-
95-56-7
- ~%
-
In-stock
204377-88-8
References
-
Australian Journal of Chemistry, , vol. 63, # 11 p. 1582 - 1593
-
-
Route3
-
In-stock
165538-35-2 - ~99%
-
In-stock
204377-88-8
References
-
Patonay, Tams; Vasas, Attila; Kiss-Szikszai, Attila; Silva, Artur M. S.; Cavaleiro, Jos A. S. Australian Journal of Chemistry, 2010 , vol. 63, # 11 p. 1582 - 1593
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H319
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 26.3
- LogP 2.4143
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 0
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 8-Bromochroman-4-one sigma8-Bromochroman-4-one manufacturer8-Bromochroman-4-one price8-Bromochroman-4-one structure8-Bromochroman-4-one SDSbuy 8-Bromochroman-4-one8-Bromochroman-4-one supplier8-Bromochroman-4-one uses8-Bromochroman-4-one molecular weightprice of 8-Bromochroman-4-one8-Bromochroman-4-one chemical name formula of 8-Bromochroman-4-one