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CS-W001157 4
Total: USD 88.00

Biotin-PEG4-acid

  • CAS No. 721431-18-1

  • Cat. No. CS-0108924
  • Purity≥97%
  • MDL No.MFCD08457831

*For research and further manufacturing use only, not for direct human use.

Biotin-PEG4-acid|CS-0108924

Structure of 721431-18-1

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General Information

  • CAS No. 721431-18-1
  • Cat. No. CS-0108924
  • Purity ≥97%
  • MDL No. MFCD08457831
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₃₇N₃O₈S
  • Molecular Weight 491.60
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O

Description

Biotin-PEG4-acid offers a robust, hydrophilic linker for conjugating biomolecules via amine-reactive ester formation. The PEG4 spacer enhances solubility and reduces non-specific binding, while the terminal carboxylic acid enables site-specific coupling. This derivative integrates seamlessly into bioconjugation workflows requiring stable, water-compatible linkages.

Application

Biotin-PEG4-acid serves as a versatile bifunctional linker for bioconjugation, combining the high-affinity biotin-binding property with a hydrophilic PEG4 spacer. The terminal carboxylic acid enables efficient coupling to amine-containing biomolecules via standard activation methods (e.g., EDC/NHS), while the PEG4 chain minimizes non-specific binding and enhances solubility. Its bench-stable, well-characterized structure facilitates reliable conjugation workflows in immunoassays, protein labeling, and targeted delivery applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   144.45
  • LogP   0.3695
  • H_Acceptors   8
  • H_Donors   4
  • Rotatable_Bonds   20

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