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CS-W001157 4
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Biotin-PEG3-acid

  • CAS No. 252881-76-8

  • Cat. No. CS-0063554
  • Purity≥95%
  • MDL No.MFCD22574817

*For research and further manufacturing use only, not for direct human use.

Biotin-PEG3-acid|CS-0063554

Structure of 252881-76-8

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General Information

  • CAS No. 252881-76-8
  • Cat. No. CS-0063554
  • Purity ≥95%
  • MDL No. MFCD22574817
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₃₃N₃O₇S
  • Molecular Weight 447.55
  • Synonym(s) None
  • SMILES O=C1N[C@]2(CS[C@H]([C@]2(N1)[H])CCCCC(NCCOCCOCCOCCC(O)=O)=O)[H]

Description

Biotin-PEG3-acid is a water-soluble linker featuring a triethylene glycol spacer that connects biotin to a terminal carboxylic acid. This structure enables efficient conjugation to amine-functionalized biomolecules via standard coupling chemistries. The PEG3 moiety enhances solubility and reduces non-specific binding, while the biotin group provides high-affinity recognition for streptavidin and avidin systems. Ideal for bioconjugation applications requiring both stability and ease of functionalization.

Application

Biotin-PEG3-acid serves as a versatile bifunctional linker for bioconjugation, enabling site-specific labeling via its terminal carboxylic acid and high-affinity biotin moiety. The three-ethylene glycol spacer provides enhanced solubility and reduced steric hindrance, facilitating efficient conjugation to amines under standard coupling conditions. Its bench-stable structure supports reliable use in protein labeling, affinity purification, and diagnostic assay development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   135.22
  • LogP   0.3529
  • H_Acceptors   7
  • H_Donors   4
  • Rotatable_Bonds   17

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