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Structure of 71701-92-3
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3-Bromo-2-chloro-5-(trifluoromethyl)pyridine is a halogenated pyridine derivative featuring orthogonal reactivity at bromo and chloro positions, enabling sequential cross-coupling. The trifluoromethyl group imparts enhanced electron-withdrawal and metabolic stability, while the molecule exhibits bench-stable handling under standard conditions. This structure facilitates precise functionalization in medicinal chemistry and materials synthesis.
3-Bromo-2-chloro-5-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the ortho-halogen substitution pattern facilitates selective functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for constructing complex heterocyclic scaffolds in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301
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Precautionary Statements : P264-P270-P301+P310-P330-P405-P501
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Lot numbers can be found on the outside label of a product: