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CS-W001157 4
Total: USD 88.00

5-Bromo-2-chloro-3-(difluoromethyl)pyridine

  • CAS No. 1332392-76-3

  • Cat. No. CS-0142305
  • Purity≥97%
  • MDL No.MFCD22199307

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-chloro-3-(difluoromethyl)pyridine|CS-0142305

Structure of 1332392-76-3

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General Information

  • CAS No. 1332392-76-3
  • Cat. No. CS-0142305
  • Purity ≥97%
  • MDL No. MFCD22199307
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClF₂N
  • Molecular Weight 242.45
  • Synonym(s) None
  • SMILES FC(C1=CC(Br)=CN=C1Cl)F

Description

5-Bromo-2-chloro-3-(difluoromethyl)pyridine features a sterically constrained pyridine core bearing bromo, chloro, and difluoromethyl substituents at strategic positions. This electron-deficient heterocycle integrates readily into cross-coupling reactions, enabling efficient access to advanced pharmaceutical intermediates and functionalized materials under standard conditions.

Application

5-Bromo-2-chloro-3-(difluoromethyl)pyridine serves as a versatile building block for constructing bioactive heterocycles, enabling palladium-catalyzed cross-coupling reactions with high functional group tolerance. The difluoromethyl group enhances metabolic stability and modulates lipophilicity, while the bromo and chloro substituents facilitate sequential functionalization. Its bench-stable nature and compatibility with standard synthetic workflows make it ideal for medicinal chemistry and process development applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.4351
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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