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CS-W001157 4
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2-(5-Bromothiophen-2-yl)acetic acid

  • CAS No. 71637-38-2

  • Cat. No. CS-0136802
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(5-Bromothiophen-2-yl)acetic acid|CS-0136802

Structure of 71637-38-2

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General Information

  • CAS No. 71637-38-2
  • Cat. No. CS-0136802
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrO₂S
  • Molecular Weight 221.07
  • Synonym(s) 2-(5-Bromo-2-thienyl)acetic Acid
  • SMILES O=C(O)CC1=CC=C(Br)S1

Description

This brominated thiophene-acetic acid derivative integrates a reactive carboxylate group with a sterically accessible bromine substituent. The para-brominated thiophene moiety enables direct functionalization in cross-coupling reactions, while the pendant acetic acid facilitates conjugation or derivatization under standard conditions. Bench-stable and moisture-tolerant, it serves as a key building block for bioactive heterocycles and advanced materials synthesis.

Application

2-(5-Bromothiophen-2-yl)acetic acid serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized thiophene derivatives. Its bromo-substituted heterocyclic core facilitates palladium-catalyzed cross-coupling reactions, while the pendant acetic acid group offers direct handle for amidation, esterification, or further derivatization. The compound exhibits good bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis workflows in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.1377
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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