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CS-W001157 4
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2-(4-Bromothiophen-2-yl)acetic acid

  • CAS No. 161942-89-8

  • Cat. No. CS-0157332
  • Purity≥96%
  • MDL No.MFCD09839310

*For research and further manufacturing use only, not for direct human use.

2-(4-Bromothiophen-2-yl)acetic acid|CS-0157332

Structure of 161942-89-8

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General Information

  • CAS No. 161942-89-8
  • Cat. No. CS-0157332
  • Purity ≥96%
  • MDL No. MFCD09839310
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrO₂S
  • Molecular Weight 221.07
  • Synonym(s) 4-Bromothiophene-2-acetic acid
  • SMILES C1=C(CC(=O)O)SC=C1Br

Description

This bromothiophene-acetic acid derivative features a reactive carboxylic acid group flanked by a brominated thiophene ring, enabling direct incorporation into cross-coupling reactions. The electron-deficient thiophene moiety enhances compatibility with palladium-catalyzed transformations, while the bench-stable structure simplifies handling in synthetic workflows.

Application

2-(4-Bromothiophen-2-yl)acetic acid serves as a versatile building block for constructing biologically relevant heterocyclic scaffolds and pharmaceutical intermediates. Its brominated thiophene moiety enables efficient palladium-catalyzed cross-coupling reactions, while the carboxylic acid group facilitates direct derivatization or salt formation. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.1377
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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