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CS-W001157 4
Total: USD 88.00

2-Propoxybenzaldehyde

  • CAS No. 7091-12-5

  • Cat. No. CS-0084129
  • Purity≥98%
  • MDL No.MFCD00046150

*For research and further manufacturing use only, not for direct human use.

2-Propoxybenzaldehyde|CS-0084129

Structure of 7091-12-5

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General Information

  • CAS No. 7091-12-5
  • Cat. No. CS-0084129
  • Purity ≥98%
  • MDL No. MFCD00046150
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂O₂
  • Molecular Weight 164.20
  • Synonym(s) 2-n-Propoxybenzaldehyde
  • SMILES O=CC1=CC=CC=C1OCCC

Description

2-Propoxybenzaldehyde features a para-propoxy substituent that enhances solubility in organic media while maintaining reactivity at the aldehyde group. This electron-donating ether stabilizes intermediates in coupling reactions and facilitates efficient functionalization in synthetic pathways requiring polar, bench-stable aromatic aldehydes.

Application

2-Propoxybenzaldehyde serves as a versatile synthetic intermediate for the construction of functionalized aromatic scaffolds. Its aldehyde functionality enables efficient coupling reactions, while the ortho-propoxy group provides steric and electronic modulation. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in medicinal chemistry campaigns and heterocycle synthesis.

Synthesis

  • Route1

    References

    • Ikawa, Takashi; Sajiki, Hironao; Hirota, Kosaku Tetrahedron, 2005 , vol. 61, # 8 p. 2217 - 2231
  • Route2
    • null|null
      90-02-8
    • null|null
      106-94-5
    • ~65%
    • In-stock
      2-Propoxybenzaldehyde|CS-0084129
      7091-12-5

    References

    • ASTRAZENECA AB Patent: WO2005/40167 A1, 2005 ; Location in patent: Page/Page column 58 ; WO 2005/040167 A1
  • Route3
    • null|null
      90-02-8
    • null|null
      107-08-4
    • ~54%
    • In-stock
      2-Propoxybenzaldehyde|CS-0084129
      7091-12-5

    References

    • Horaguchi, Takaaki; Tsukada, Chikara; Hasegawa, Eietsu; Shimizu, Takahachi; Suzuki, Tsuneo; Tanemura, Kiyoshi Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 5 p. 1261 - 1272

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.2879
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   4

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