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7-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

  • CAS No. 867034-08-0

  • Cat. No. CS-0050052
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid|CS-0050052

Structure of 867034-08-0

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General Information

  • CAS No. 867034-08-0
  • Cat. No. CS-0050052
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClN₂O₂
  • Molecular Weight 196.59
  • Synonym(s) 1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid, 7-chloro
  • SMILES OC(=O)C1=CC2=CC=NC(Cl)=C2N1

Description

7-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid features a rigid, electron-deficient heterocyclic core that integrates seamlessly into bioactive scaffolds. The carboxylic acid group enables direct coupling or derivatization under standard conditions, while the chloro substituent enhances electrophilic reactivity and modulates electronic properties for targeted molecular design in medicinal chemistry applications.

Application

7-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyrrolopyridine-based scaffolds prevalent in medicinal chemistry. The carboxylic acid functionality facilitates direct coupling reactions, while the chloro substituent provides a handle for palladium-catalyzed cross-coupling transformations. Bench-stable and compatible with standard purification methods, it functions effectively in multistep syntheses requiring functional group tolerance and structural rigidity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.9145
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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