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CS-W001157 4
Total: USD 88.00

6-(Trifluoromethyl)pyrazin-2-amine

  • CAS No. 69816-35-9

  • Cat. No. CS-W006954
  • Purity≥95%
  • MDL No.MFCD10697803

*For research and further manufacturing use only, not for direct human use.

6-(Trifluoromethyl)pyrazin-2-amine|CS-W006954

Structure of 69816-35-9

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General Information

  • CAS No. 69816-35-9
  • Cat. No. CS-W006954
  • Purity ≥95%
  • MDL No. MFCD10697803
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄F₃N₃
  • Molecular Weight 163.10
  • Synonym(s) 6-Trifluoromethyl-pyrazin-2-ylamine
  • SMILES NC1=NC(C(F)(F)F)=CN=C1

Description

6-(Trifluoromethyl)pyrazin-2-amine features a trifluoromethyl group at the 6-position of the pyrazine ring, imparting enhanced electron-withdrawing character and metabolic stability. This nitrogen-rich heterocycle integrates readily into pharmaceutical scaffolds, offering improved solubility and binding affinity in targeted kinase inhibitors and bioactive molecule design.

Application

6-(Trifluoromethyl)pyrazin-2-amine serves as a versatile building block in medicinal chemistry, enabling direct incorporation of the electron-withdrawing trifluoromethyl group into pyrazine-based scaffolds. Its stability under standard synthetic conditions and compatibility with palladium-catalyzed cross-coupling reactions facilitate efficient diversification. Functions as a key intermediate for targeted heterocyclic compound synthesis, particularly in kinase inhibitor and agrochemical development.

Synthesis

  • Route1

    References

    • Eli Lilly and Company Patent: US4293552 A1, 1981 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.0776
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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