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CS-W001157 4
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5-(Difluoromethyl)pyrazin-2-amine

  • CAS No. 1785551-80-5

  • Cat. No. CS-0505241
  • Molecule weight145.11
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(Difluoromethyl)pyrazin-2-amine|CS-0505241

Structure of 1785551-80-5

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General Information

  • CAS No. 1785551-80-5
  • Cat. No. CS-0505241
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅F₂N₃
  • Molecular Weight 145.11
  • Synonym(s) None
  • SMILES NC1=NC=C(C(F)F)N=C1

Description

5-(Difluoromethyl)pyrazin-2-amine integrates a difluoromethyl group at the 5-position of pyrazin-2-amine, delivering enhanced metabolic stability and improved lipophilicity. This electron-deficient heterocycle features a polar amine functionality that facilitates hydrogen bonding and solubility in aqueous media. The compound serves as a key building block for bioactive molecules in medicinal chemistry, particularly in kinase inhibitor and antiviral agent development.

Application

5-(Difluoromethyl)pyrazin-2-amine serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group into heterocyclic scaffolds. Its pyrazine core provides a rigid, electron-deficient platform that facilitates transition-metal-catalyzed cross-couplings and nucleophilic substitutions. The difluoromethyl functionality enhances metabolic stability and modulates electronic properties, offering favorable lipophilicity and bioavailability profiles. This compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis campaigns in drug discovery.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.9964
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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