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Structure of 1785551-80-5
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5-(Difluoromethyl)pyrazin-2-amine integrates a difluoromethyl group at the 5-position of pyrazin-2-amine, delivering enhanced metabolic stability and improved lipophilicity. This electron-deficient heterocycle features a polar amine functionality that facilitates hydrogen bonding and solubility in aqueous media. The compound serves as a key building block for bioactive molecules in medicinal chemistry, particularly in kinase inhibitor and antiviral agent development.
5-(Difluoromethyl)pyrazin-2-amine serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group into heterocyclic scaffolds. Its pyrazine core provides a rigid, electron-deficient platform that facilitates transition-metal-catalyzed cross-couplings and nucleophilic substitutions. The difluoromethyl functionality enhances metabolic stability and modulates electronic properties, offering favorable lipophilicity and bioavailability profiles. This compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis campaigns in drug discovery.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: