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CS-W001157 4
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6-Bromo-3-fluoropyridine-2-carbaldehyde

  • CAS No. 885267-36-7

  • Cat. No. CS-0050277
  • Purity≥97%
  • MDL No.MFCD07781224

*For research and further manufacturing use only, not for direct human use.

6-Bromo-3-fluoropyridine-2-carbaldehyde|CS-0050277

Structure of 885267-36-7

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General Information

  • CAS No. 885267-36-7
  • Cat. No. CS-0050277
  • Purity ≥97%
  • MDL No. MFCD07781224
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrFNO
  • Molecular Weight 204.00
  • Synonym(s) None
  • SMILES FC1=CC=C(Br)N=C1C=O

Description

6-Bromo-3-fluoropyridine-2-carbaldehyde features a trifunctional pyridine core bearing bromo, fluoro, and aldehyde groups in a regioselective arrangement. This electron-deficient heterocycle serves as a high-value building block for pharmaceutical intermediates, enabling direct coupling or derivatization under standard conditions. The aldehyde functionality facilitates rapid functionalization via nucleophilic addition or condensation reactions.

Application

6-Bromo-3-fluoropyridine-2-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogenation pattern. The aldehyde group facilitates imine formation and reductive amination, while the fluorine and bromine substituents offer strategic sites for further functionalization. Bench-stable and compatible with standard purification protocols, it functions reliably in multi-step syntheses of heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.7957
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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