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CS-W001157 4
Total: USD 88.00

4-Chloro-2,6-difluoroaniline

  • CAS No. 69411-06-9

  • Cat. No. CS-W016103
  • Purity≥98%
  • MDL No.MFCD03426173

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2,6-difluoroaniline|CS-W016103

Structure of 69411-06-9

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General Information

  • CAS No. 69411-06-9
  • Cat. No. CS-W016103
  • Purity ≥98%
  • MDL No. MFCD03426173
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClF₂N
  • Molecular Weight None
  • Synonym(s) 4-Chloro-2,6-difluorobenzenamine
  • SMILES NC1=C(F)C=C(Cl)C=C1F

Description

4-Chloro-2,6-difluoroaniline delivers a trifunctional aryl scaffold with orthogonal reactivity. The electron-deficient aromatic ring enables efficient coupling in cross-coupling and amide formation reactions. This bench-stable derivative integrates readily into pharmaceutical intermediates and functional materials, offering enhanced metabolic stability and controlled electronic tuning through strategic fluorination.

Application

4-Chloro-2,6-difluoroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via electrophilic substitution and coupling reactions. Its ortho-fluoro substituents enhance reactivity in palladium-catalyzed cross-couplings, while the chloro group provides a handle for further functionalization. Bench-stable and compatible with standard purification methods, it facilitates streamlined synthesis of complex molecular architectures.

Synthesis

  • Route1

    References

    • WO2012/110860 A1, ; Page/Page column 47 ; WO 2012/110860 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.2004
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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