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CS-W001157 4
Total: USD 88.00

4-Aminocyclohexan-1-ol

  • CAS No. 6850-65-3

  • Cat. No. CS-W019318
  • Purity≥95%
  • MDL No.MFCD00042624

*For research and further manufacturing use only, not for direct human use.

4-Aminocyclohexan-1-ol|CS-W019318

Structure of 6850-65-3

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General Information

  • CAS No. 6850-65-3
  • Cat. No. CS-W019318
  • Purity ≥95%
  • MDL No. MFCD00042624
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃NO
  • Molecular Weight 115.17
  • Synonym(s) trans-4-Aminocyclohexanol
  • SMILES C1C(CCC(C1)O)N

Description

4-Aminocyclohexan-1-ol features a cyclohexane ring bearing both amino and hydroxyl substituents at opposing positions, enabling dual functionalization. This bifunctional scaffold supports conjugation strategies in medicinal chemistry and polymer synthesis. The molecule exhibits enhanced solubility in polar solvents and stability under standard bench conditions, facilitating handling in process development workflows.

Application

4-Aminocyclohexan-1-ol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and cyclic amine scaffolds. Its bifunctional nature—combining a primary amine and a secondary alcohol—facilitates orthogonal functionalization, protecting group strategies, and macrocyclization. The compound exhibits excellent bench stability and is compatible with standard coupling, reductive amination, and cyclization protocols, making it well-suited for lead optimization and process-scale synthesis.

Synthesis

  • Route1

    References

    • US6369274 B1, ; Page column 3 ;
  • Route2
    • null|null
      100-02-7
    • ~%
    • In-stock
      4-Aminocyclohexan-1-ol|CS-W019318
      6850-65-3
    • null|null
      123-30-8

    References

    • Catalysis Communications, , vol. 18, p. 55 - 59
  • Route3
    • In-stock
      4-(4-Methylphenoxy)aniline|CS-0117157
      41295-20-9
    • ~%
    • In-stock
      4-Aminocyclohexan-1-ol|CS-W019318
      6850-65-3
    • null|null
      82166-21-0

    References

    • Chemical Communications, , vol. 49, # 40 p. 4567 - 4569

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H314-H410
Precautionary Statements : P264-P270-P273-P280-P304+P340-P330-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   0.2486
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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