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CS-W001157 4
Total: USD 88.00

1-Benzyl-4-chloropiperidine

  • CAS No. 67848-71-9

  • Cat. No. CS-0156295
  • Purity≥97%
  • MDL No.MFCD00510091

*For research and further manufacturing use only, not for direct human use.

1-Benzyl-4-chloropiperidine|CS-0156295

Structure of 67848-71-9

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General Information

  • CAS No. 67848-71-9
  • Cat. No. CS-0156295
  • Purity ≥97%
  • MDL No. MFCD00510091
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆ClN
  • Molecular Weight 209.72
  • Synonym(s) N-BENZYL-4-CHLORO-PIPERIDINE
  • SMILES C1=CC=C(C=C1)CN2CCC(CC2)Cl

Description

1-Benzyl-4-chloropiperidine is a sterically hindered, bench-stable piperidine derivative featuring a chloro substituent at the 4-position and a benzyl group at nitrogen. This combination imparts enhanced lipophilicity and metabolic stability, enabling efficient incorporation into bioactive molecules. The compound serves as a key building block in medicinal chemistry for targeted CNS drug development.

Application

1-Benzyl-4-chloropiperidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. The chloro group at the 4-position facilitates nucleophilic substitution reactions, while the benzyl-protected piperidine core offers enhanced stability and ease of purification. Its functional group tolerance supports downstream modifications in multi-step syntheses, making it well-suited for pharmaceutical R&D workflows requiring reliable reactivity and bench-scale handling.

Synthesis

  • Route1

    References

    • Larsen, Scott D.; Grieco, Paul A.; Fobare, William F. Journal of the American Chemical Society, 1986 , vol. 108, # 12 p. 3512 - 3513
  • Route2
    • null|null
      127073-71-6
    • ~68%
    • In-stock
      1-Benzyl-4-chloropiperidine|CS-0156295
      67848-71-9

    References

    • Yang, Teng-Kuei; Hung, Shun-Ming; Lee, Dong-Sheng; Hong, An-Way; Cheng, Chan-Chun Tetrahedron Letters, 1989 , vol. 30, # 37 p. 4973 - 4976
  • Route3
    • null|null
      4727-72-4
    • ~81%
    • In-stock
      1-Benzyl-4-chloropiperidine|CS-0156295
      67848-71-9

    References

    • Lizarzaburu, Mike E.; Shuttleworth, Stephen J. Tetrahedron Letters, 2003 , vol. 44, # 26 p. 4873 - 4876

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   3.24
  • LogP   2.8898
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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